noun
heavy blow; major blow; severe damage
Used for a serious setback, shock, or damage, often in emotional, financial, or reputational contexts. Can be literal (physical strike) but more often figurative.
そのニュースは彼にとって大打撃だった。
The news was a heavy blow to him.
不況で会社は大打撃を受けた。
The company suffered a major blow due to the recession.